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The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats

✍ Scribed by Atsushi Gojo; Kazunori Utsunomiya; Kanta Taniguchi; Tamotsu Yokota; Shoh Ishizawa; Yasushi Kanazawa; Hideaki Kurata; Naoko Tajima

Book ID
113586903
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
266 KB
Volume
568
Category
Article
ISSN
0014-2999

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Curcumin attenuates diabetic nephropathy
Curcumin attenuates diabetic nephropathy by inhibiting PKC-Ξ± and PKC-Ξ²1 activity in streptozotocin-induced type I diabetic rats
✍ Vivian Soetikno; Kenichi Watanabe; Flori R. Sari; Meilei Harima; Rajarajan A. Th πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 362 KB

## Abstract **Scope**: We hypothesized that curcumin, a potent anti‐oxidant, might be beneficial in ameliorating the development of diabetic nephropathy through inhibition of PKC‐α and PKC‐β1 activity‐ERK1/2 pathway. **Methods and results**: Diabetes was induced by a single intraperitoneal injecti