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The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras

✍ Scribed by Ho, V M; Schaffer, B E; Karnezis, A N; Park, K S; Sage, J

Book ID
109970827
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
322 KB
Volume
28
Category
Article
ISSN
0950-9232

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✍ Toshifumi Tsujiuchi; Yasutaka Sasaki; Yoichi Konishi; Masahiro Tsutsumi 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 124 KB

## Abstract Alteration of the retinoblastoma‐related gene __RB2/p130__ was investigated in lung adenocarcinomas induced by __N__‐nitrosobis(2‐hydroxypropyl)amine (BHP) in male Wistar rats. At 6 wk of age, 21 animals were given 2000 ppm of BHP in their drinking water for 12 wk and then maintained wi