Resolution of racemic cis-1-amino-2-indanol 1, a key intermediate for the synthesis of indinavir, is reported. The conditions were optimized for an industrial-scale resolution of racemic cis-1 using (S)-2-phenylpropionic acid 6 as the resolving agent and ethanol as the solvent. The less-soluble dias
THE RESOLUTION OF RACEMIC AMINES BY THE FORMATION OF DIASTEREOMERIC AMIDES WITH AMINO ACIDS
✍ Scribed by Miao, Clara K.; Sorcek, Ronald; Nagel, Jürgen H.
- Book ID
- 121292501
- Publisher
- Taylor and Francis Group
- Year
- 1992
- Tongue
- English
- Weight
- 274 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0030-4948
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## Abstract The resolution of racemates through their diastereomeric salts can be positively affected by the addition of small amounts of suitable nucleation inhibitors. This discovery is a logical extension of “Dutch Resolution”, in which equimolar amounts of resolving agents that are members of t
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