The Representation of Combinatorial Libraries
β Scribed by Derek Maclean; Eric J. Martin
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 48 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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## Abstract For Abstract see ChemInform Abstract in Full Text.
Most agrochemical and pharmaceutical companies have set up high-throughput screening programs which require large numbers of compounds to screen. Combinatorial libraries provide an attractive way to deliver these compounds. A single combinatorial library with four variable positions can yield more t
We first review existing computational methods with an intrinsic combinatorial feature, then describe a new computational method for screening combinatorial libraries using a recently developed multicopy sampling technique. The new method differs from the existing ones in that it can be used to scre
It is not enough to select a chemistry, build a combinatorial library, and test it for biologically active compounds. Chemical libraries can serve different purposes and it is reasonable that they should be designed in light of their purpose and the information available on structural properties imp