๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

The Design of Leadlike Combinatorial Libraries

โœ Scribed by Simon J. Teague; Andrew M. Davis; Paul D. Leeson; Tudor Oprea


Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
167 KB
Volume
38
Category
Article
ISSN
0044-8249

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


Genetic optimization of combinatorial li
โœ Alberto Gobbi; Dieter Poppinger ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 167 KB

Most agrochemical and pharmaceutical companies have set up high-throughput screening programs which require large numbers of compounds to screen. Combinatorial libraries provide an attractive way to deliver these compounds. A single combinatorial library with four variable positions can yield more t

Rational design of a targeted combinator
โœ Weifan Zheng; Sung Jin Cho; Alexander Tropsha ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 241 KB ๐Ÿ‘ 1 views

We describe a new computational approach, called Focus-2D, to the rational design of targeted combinatorial chemical libraries. This approach is based on the hypothesis that structurally similar compounds display similar biological activity profiles. Building blocks that are used in a combinatorial