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The repertoire of human tumor-associated epitopes — identification and selection of antigens and their application in clinical trials

✍ Scribed by Haen, Sebastian P; Rammensee, Hans-Georg

Book ID: 120921727
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 339 KB
Volume: 25
Category: Article
ISSN: 0952-7915
DOI: 10.1016/j.coi.2013.03.007

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Previous studies have shown that self-antigens overexpressed in malignant tissue can provide a basis for a tumorspecific immune response. The mucin MUC2 is strongly overexpressed in all mucinous tumors of colon, breast, ovary and pancreas. In the corresponding normal tissue it is either not expresse