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The repair process in experimentally induced avascular necrosis of the femoral head in dogs

โœ Scribed by Kunio Takaoka; Toshiro Yoshioka; Tohru Hosoya; Keiro Ono; Tadashi Takase

Publisher
Springer
Year
1981
Tongue
English
Weight
807 KB
Volume
99
Category
Article
ISSN
1434-3916

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โœฆ Synopsis

Total necrosis of the femoral head was experimentally produced in dogs by freezing The healing process was observed in a time sequence There was a dense fibrous layer at the boundary between the necrotic bone mass and living bone tissue, in each dog which survived for 18 months after the surgery The layers were similar to that commonly found in avascular necrosis of the femoral head in humans Histological observation revealed that the establishment of the dense fibrous layer was the final result of three time dependent changes in biological potencies of granulation tissue, i e , decreasing proliferating and differentiating potencies and increasing osteoclastic potency of mesenchymal cells within the granulation tissue.

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## Abstract Avascular necrosis of bone (AVNB) is a wellโ€known but rare complication of chemotherapy for lymphoma with a reported incidence ranging from 1 to 10 per cent. Early diagnosis is essential for optimal therapeutic management. Using MRI, the most sensitive means of detecting the earlier sta