✦ LIBER ✦

Diagnosis of avascular necrosis of the femoral head in patients treated for lymphoma

✍ Scribed by Dr Marcia A. Ratcliffe; Fiona J. Gilbert; Audrey A. Dawson; Bruce Bennett

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 557 KB
Volume: 13
Category: Article
ISSN: 0278-0232
DOI: 10.1002/hon.2900130303

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Avascular necrosis of bone (AVNB) is a well‐known but rare complication of chemotherapy for lymphoma with a reported incidence ranging from 1 to 10 per cent. Early diagnosis is essential for optimal therapeutic management. Using MRI, the most sensitive means of detecting the earlier stages of AVNB, 100 patients treated with standard chemotherapy for lymphoma were assessed. Fifteen were found to have changes of AVNB, 10 with early changes but five with advanced segmental collapse of the femoral head. None with AVNB had more than the standard course of corticosteroids.

Almost a quarter of the study group complained of joint pain during and/or after their treatment, a third of whom were found to have AVNB; a strong indicator to screen all those with pain. However, 40 per cent of those with AVNB were asymptomatic. The clinical significance of the‘silent hip’ is yet to be elucidated.

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