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The Remarkable Transport Mechanism of P-Glycoprotein: A Multidrug Transporter

โœ Scribed by Marwan K. Al-Shawi; Hiroshi Omote

Book ID
106402211
Publisher
Springer US
Year
2005
Tongue
English
Weight
149 KB
Volume
37
Category
Article
ISSN
0145-479X

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A novel hypothesis for the mechanism of
A novel hypothesis for the mechanism of action of P-glycoprotein as a multidrug transporter
โœ Bao Ting Zhu ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 172 KB ๐Ÿ‘ 1 views

For years, P-glycoprotein (P-gp) has been purported to be a membrane transporter capable of selectively transporting many (but not all) lipophilic anticancer drugs with diverse chemical structures. Because the alleged functions of P-gp provide a straightforward, near-perfect explanation for the mole