Clinicians have long observed that treatment with one anticancer drug can confer resistance to that drug and to other anticancer drugs with different chemical structures and mechanisms of action. This is the multidrug resistance (MDR) phenomenon, which frequently occurs in the absence of previous ch
Cortisol is transported by the multidrug resistance gene product P-glycoprotein
β Scribed by van Kalken, CK; Broxterman, HJ; Pinedo, HM; Feller, N; Dekker, H; Lankelma, J; Giaccone, G
- Book ID
- 109836951
- Publisher
- Nature Publishing Group
- Year
- 1993
- Tongue
- English
- Weight
- 1009 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0007-0920
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P-Glycoprotein (PGP), a product of the multidrug resistance gene (mdr), acts as an adenosine triphosphate-dependent drug efflux system in cells. Initially, PGP was found in cancer cells, but it is now known that PGP is richly distributed in the adult brain. Passage to the central nervous system is l
## BACKGROUND. It has been observed that patients who have previously undergone radiotherapy have a lower rate of response to chemotherapy. ## METHODS. The authors investigated the effects of radiation on the expression of P-glycoprotein (Pgp), a multidrug-resistance gene product, in 56 patient