Expression of P-glycoprotein, a multidrug-resistance gene product, is Induced by radiotherapy in patients with oral squamous cell carcinoma
✍ Scribed by Irene O. L. Ng; King Y. Lam; Matthew Ng; Dora L.W. Kwong; Jonathan S. T. Sham
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 509 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
BACKGROUND. It has been observed that patients who have previously undergone
radiotherapy have a lower rate of response to chemotherapy.
METHODS.
The authors investigated the effects of radiation on the expression of P-glycoprotein (Pgp), a multidrug-resistance gene product, in 56 patients with primary oral cancer. No patients received prior or concurrent chemotherapy. The 56 patients consisted of 3 groups: 1) 20 patients with preradiation or pretreatment specimens only, 2) 18 patients with both pre-and postradiation specimens, and 3) 18 patients with postradiation specimens only. Pgp expression was determined by immunohistochemistry with two monoclonal antibodies, C219 and C494.