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The relaxivity of Gd-EOB-DTPA and Gd-DTPA in liver and kidney of the Wistar rat

✍ Scribed by B. Shuter; P.S. Tofts; S.-C. Wang; J.M. Pope

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
976 KB
Volume
14
Category
Article
ISSN
0730-725X

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✦ Synopsis

The NMR relaxivities of GQEOB-DTPA and Gd-DTPA were determined in the kidney and liver of intact male W&tar rats immediately following sacrifice and in vitro in solutions and gels, at 1.5 T using a clinical MR scanner. Tl and T2 values of tissue samples were derived from spin-echo image sequences. Tissue gadolinium concentrations were determined by radioassay of Gd ls3. Gd-EOB-DTPA Tl and T2 relaxivities, R, and Rz (s-l mmole-' kg), were found to be 10.7 i: 0.5 and 22.5 + 3.2, respectively, for liver, 2.4 + 0.2 and 12.1 2 1.7 for kidney cortex, 2.7 2 0.2 and 14.5 ? 1.9 for kidney outer medulla, 2.0 t 0.2 and 11.4 2 2.1 for kidney inner medulla. Gd-DTPA RI and R2 were found to be 4.8 2 0.4 and 14.5 t 3.7 for liver, 1.2 -+ 0.1 and 7.9 2 0.8 for kidney cortex, 1.6 2 0.1 and 10.2 + 1.4 for kidney outer medulla, 1.3 ? 0.1 and 10.2 + 1.2 for kidney inner medulla. Gd-EOB-DTPA and Gd-DTPA R, was increased in liver compared to agarose gels at 38°C (4.49 t 0.03 and 3.47 t 0.06), but reduced in kidney tissues. All R2 were elevated compared to agarose gels at 38°C (5.72 -t 0.12 and 4.12 2 0.03). Elevated Rz and RI (expressed in terms of the concentration of gadolinium per kg of tissue) can be accounted for in part by the lower water content of tissues compared with gels or solutions, increased microviscosity and binding to macromolecules. In addition, susceptibility effects may give rise to further increases in R2. By contrast, the reduced RI observed in kidney may be the result of compartmentalization of the magnetopharmaceuticals. Statistically improved fits were obtained for Tl recovery curves for liver in the presence of Gd-EOB-DTPA when a dual exponential model was used. Assuming in vitro values for the relaxivities of these artificial contrast agents will lead to inaccuracies when relating observed signal enhancement factors to tissue gadolinium concentration.

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