The relative configurations of the diastbreombrs of the dl-3-amino-2-methylbutyric acid; a convenient method for their preparation via the Hofmann rearrangement

✍ Scribed by Ivan G. Pojarlieff; Bogdan I. Kurtev

• Book ID: 104241859
• Publisher: Elsevier Science
• Year: 1963
• Tongue: French
• Weight: 138 KB
• Volume: 4
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)90666-5

✦ Synopsis

11: a .jrevious i >a':'-'??" the syz.t!xoi.o of 3-anino-2-inethylbutyric acid by the Rodiozow reactioc 2 from acetaldehyde-amonia and :Ilctilyl:.lalo;lic acid *;]a0 reported. 'Tno diastareonors witi; m.p. 227-223" dcc. aid 213-214" dot. were isolated and several of their dorivativcs obtaii?ed. Ix order to establish the relative confi c;ratic-f:s of the two asymmetric carbon atom of the two axi:xo acid diaatereomrs we used the I:ofrmr~ii rearrangenc!t nhicl: ha0 bee'.: :>roved3 to proceed wit:; reteiztioa of the cc-figuratio?; of t;le carbon, atorn attac?;ed to tile a&de Croup. ior t:iis purpose we prepared the ixide of oL-2,3-dix~ethylsuccinic acid (I) a!:d the i.!O:iOtV.lidC Of %3f30-2,~-di.net~:ykiUcci~ic acid (II). zho configuration of these corqounds ha0 been carefully 1 13.1. iiurtev and I. Pojarlioff, Coinotns rerdua, Acad. bulg. sc.