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The relationship between mucosal cyclooxygenase-2 (COX-2) expression and experimental radiation-induced mucositis

✍ Scribed by S.T. Sonis; K.E. O'Donnell; R. Popat; C. Bragdon; S. Phelan; D. Cocks; J.B. Epstein

Book ID: 114394061
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 487 KB
Volume: 40
Category: Article
ISSN: 1368-8375
DOI: 10.1016/s1368-8375(03)00148-9

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## Abstract The mechanisms whereby cyclooxygenase‐2 (COX‐2) overexpression may contribute to bladder carcinogenesis remain unknown. We recently developed a transgenic mouse model overexpressing COX‐2 under the control of a bovine keratin 5 (BK5) promoter causing a high incidence of transitional cel