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The relationship between increased folate catabolism and the increased requirement for folate in pregnancy

✍ Scribed by John R. Higgins; Eoin P. Quinlivan; Joseph McPartlin; John M. Scott; Donald G. Weir; Michael R. N. Darling


Book ID
111159735
Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
530 KB
Volume
107
Category
Article
ISSN
1470-0328

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Folate receptor (FR) has been proposed as a promising target for tumor drug targeting. The aim of this study was to increase the chemo-sensitivity of FR-positive cells to doxorubicin by folate-directed enzyme prodrug therapy (FDEPT). Folate conjugated penicillin-G amidase was prepared and its abilit