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The relationship between buspirone bioavailability and dose in healthy subjects

✍ Scribed by Dr. R. E. Gammans; R. F. Mayol; A. V. MacKenthun; L. F. Sokya

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
319 KB
Volume
6
Category
Article
ISSN
0142-2782

No coin nor oath required. For personal study only.

✦ Synopsis

Dose dependency of the pharmacokinetics of buspirone, a new anxiolytic agent, was tested in 24 healthy volunteers. Each subject received 10, 20, and 40 mg doses according to a randomized, three-way crossover design with a 7-day interval between treatments. Buspirone AUC values at 10, 20, and 40 mg doses were in the ratio of 1:1.7:3.5 while C,,, values had a ratio of 1:1.9:3-7. The dose normalized (10 mg basis) AUC and C,,, values, T,,, values, and half-lives were not significantly different (p > 0.05 among the doses. Buspirone half-life did not change as a function of dose (mg doses in the therapeutic range.

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