✦ LIBER ✦

Relationship between plasma propranolol concentration and dose in young, healthy volunteers

✍ Scribed by Mike Dey; Jerry Brisson; Gloria Davis; Robin Enever; Kathryn Pray; Beyhan Zaim; Dushan Dvornik

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 389 KB
Volume: 7
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510070202

No coin nor oath required. For personal study only.

✦ Synopsis

The relationship between dose and bioavailability of propranolol was determined in 12 healthy male subjects. The doses employed were 10, 40, 80 or 160mg of propanolol HCI given three times daily for 4 days. Daily minimum plasma levels showed that there was no accumulation of the drug. In all subjects, non-linear relationships were observed between peak plasma level, or area under the plasma concentration-time curve, and dose. The between subject variation of these parameters was not dose related.

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