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The regulation of DNA repair during development

✍ Scribed by David L. Mitchell; Philip S. Hartman

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
703 KB
Volume
12
Category
Article
ISSN
0265-9247

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✦ Synopsis

DNA repair is important in such phenomena as carcinogenesis and aging. While much is known about DNA repair in single-cell systems such as bacteria, yeast, and cultured mammalian cells, it is necessary to examine DNA repair in a developmental context in order to completely understand its processes in complex metazoa such as man. We present data to support the notion that proliferating cells from organ systems, tumors, and embryos have a greater DNA repair capacity than terminally differentiated, nonproliferating cells. Differential expression of repair genes and accessibility of chromatin to repair enzymes are considered as determinants in the developmental regulation of DNA repair.

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