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The regiospecific acylation of fulvenes

✍ Scribed by Howard Alper; David E. Laycock


Publisher
Elsevier Science
Year
1981
Tongue
French
Weight
117 KB
Volume
22
Category
Article
ISSN
0040-4039

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πŸ“œ SIMILAR VOLUMES


Regiospecific acylation of acetals. A co
✍ Marcos A.P. Martins; Giovani P. Bastos; Helio G. Bonacorso; Nilo Zanatta; Alex F πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 209 KB

The regiochemistry of the acylation of enol ethers, generated in situ, from acetals of unsymmetrical ketones is reported. These results demonstrate a convenient one-pot method to obtain a series of I~-methoxyvinyi trichloromethyl ketones [CCI3COCH=C(OMe)R, where R=Et, n-Bu, i-Pr, (CH2)2C(OMe)=CHC(O)

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Sumnary: Amikacin and l-N-[(S)-4-amino-2-hydroxybutyryl]-3',4'-dideoxykanamycin B have been prepared from kanamycin A and dibekacin by a novel, efficient sequence of reactions involving complex formation with Zn2+ and regiospecific N-trifluoroacetylation using ethyl trifluoroacetate.