The regiospecific acylation of fulvenes
β Scribed by Howard Alper; David E. Laycock
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- French
- Weight
- 117 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
The regiochemistry of the acylation of enol ethers, generated in situ, from acetals of unsymmetrical ketones is reported. These results demonstrate a convenient one-pot method to obtain a series of I~-methoxyvinyi trichloromethyl ketones [CCI3COCH=C(OMe)R, where R=Et, n-Bu, i-Pr, (CH2)2C(OMe)=CHC(O)
Sumnary: Amikacin and l-N-[(S)-4-amino-2-hydroxybutyryl]-3',4'-dideoxykanamycin B have been prepared from kanamycin A and dibekacin by a novel, efficient sequence of reactions involving complex formation with Zn2+ and regiospecific N-trifluoroacetylation using ethyl trifluoroacetate.