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1-N-acylation of aminocyclitol antibiotics via zinc chelation and regiospecific N-trifluoroacetylation

✍ Scribed by Tsutomo Tsuchiya; Yasushi Takagi; Sumio Umezawa

Publisher: Elsevier Science
Year: 1979
Tongue: French
Weight: 236 KB
Volume: 20
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)86759-9

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✦ Synopsis

Sumnary: Amikacin and l-N-[(S)-4-amino-2-hydroxybutyryl]-3',4'-dideoxykanamycin B have been prepared from kanamycin A and dibekacin by a novel, efficient sequence of reactions involving complex formation with Zn2+ and regiospecific N-trifluoroacetylation using ethyl trifluoroacetate.

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