Regioselective ortho lithiation of halop
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Gordon W. Gribble; Mark G. Saulnier
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Article
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1980
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Elsevier Science
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French
โ 237 KB
## Regloselective ortho llthlatlon of Z-, 3-, and 4-halopyrldlnes IS achieved with lithium dlisopropylamlde (-78", tetrahydrofuran) to afford, upon quenching with electrophlllc reagents, 2,3-and 3,4-disubstltuted pyrldlnes In good to excellent yield In connectlon with synthetic efforts underway I