Regioselective ortho lithiation of halopyridines

✍ Scribed by Gordon W. Gribble; Mark G. Saulnier

• Book ID: 104225993
• Publisher: Elsevier Science
• Year: 1980
• Tongue: French
• Weight: 237 KB
• Volume: 21
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)93671-2

✦ Synopsis

Regloselective

ortho llthlatlon of Z-, 3-, and 4-halopyrldlnes IS achieved with lithium dlisopropylamlde (-78", tetrahydrofuran) to afford, upon quenching with electrophlllc reagents, 2,3-and 3,4-disubstltuted pyrldlnes In good to excellent yield

In connectlon with synthetic efforts underway III our laboratory, we required an efficient