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The reduced folate carrier (RFC-1) gene is expressed in the murine epidermis

✍ Scribed by E. Sprecher; Reuven Bergman; Hannah Sprecher; Gila Maor; Irena Reiter; Norberto Krivoy; Stavit Drori; Yehuda G. Assaraf; Rachel Friedman-Birnbaum

Book ID: 106079388
Publisher: Springer-Verlag
Year: 1998
Tongue: English
Weight: 409 KB
Volume: 290
Category: Article
ISSN: 0340-3696
DOI: 10.1007/s004030050323

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## Abstract ## BACKGROUND High‐dose methotrexate (MTX) is an important component of current protocols for the treatment of osteosarcoma. Although MTX uptake proceeds primarily through the reduced folate carrier (RFC) protein and efflux occurs via multidrug resistance protein 1 (MRP1), RFC protein