Folate receptor-β£ (FR-β£) is generally over-expressed in non-mucinous human ovarian carcinomas. The meaning of FR-β£ over-expression and its role in the 5-methyltetrahydrofolic acid (N 5 -CH 3 -H 4 PteGlu) transport in such tumors is not clear, especially compared with the reduced folate carrier (RFC)
β¦ LIBER β¦
Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo
β Scribed by Robert Mauritz; Godefridus J. Peters; Ietje Kathmann; Habte Teshale; Paul Noordhuis; Elizabeth M. Comijn; Herbert M. Pinedo; Gerrit Jansen
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 549 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0344-5704
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## Abstract In the current study, we evaluated the efficiency of folateβpolyamidoamine dendrimers conjugates (FAβPAMAM) for the __in situ__ delivery of therapeutic antisense oligonucleotides (ASODN) that could inhibit the growth of C6 glioma cells. Folic acid was coupled to the surface amino groups