The reactions of oxo-osmium ligand complexes with isopentenyl adenine and its nucleoside

✍ Scribed by John A. Ragazzo; E.J. Behrman

• Book ID: 104106031
• Publisher: Elsevier Science
• Year: 1976
• Weight: 550 KB
• Volume: 5
• Category: Article
• ISSN: 0006-3061
• DOI: 10.1016/s0006-3061(00)80294-x

✦ Synopsis

We report syntheses of oxo-osmium(VI)bis(ligand) esters of N6-(delta2-isopentenyl) adenine (6-ipAde) and its nucleoside (IPA) which result from the addition of OsO4 to the double bond of the isopentenyl group. A study of the kinetics of these reactions shows that under typical conditions the rates of reaction relative to thymidine are as follows: for OsO4-pyridine: thymidine = 1; 6-ipAde = 4600: for OsO4-2,2'-bipyridyl: thymidine = 380; 6-ipAde = 8600; IPA = 8600. We also report syntheses of osmate esters of IPA in which the osmium is bonded through the 2'-and 3'-hydroxyl groups of the ribose residue.