The reaction of substituted ureas with sodium borohydride in pyridine
β Scribed by Yasuo Kikugawa; Shun-ichi Yamada; Hiromu Nagashima; Kenji Kaji
- Publisher
- Elsevier Science
- Year
- 1969
- Tongue
- French
- Weight
- 201 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
- We have been Investigating new types of reactions with sodium borohydrlde, the reagent, a combination of sodium borohydrlde and pyrldlne, showed a very Interesting reaction. The reduction of amides with this ed ra)ig) to give the corresponding amlnes and nltrllea by authors (S.Y. and Y.K.). In this communication, we wish tlon of ureas, which gives different results as compared reagent was report-
π SIMILAR VOLUMES
The reduction of N-alkyl pyridinium salts with sodium borohydride is a well-known reaction, yielding in most cases the corresponding 1, 2, 3, C-tetrahydropyridine derivatives. 1 The mechanistic aspects of this reaction have been studied and a mechanism proposed. 2 We wish to report our studies on t
In the course of an investigation of solvent effects on the relative reactivities of ketones with borohydridel, we have observed some unusual features of reductions in pyridine solvent which are relevant to recent discussions of the mechanism and stereochemistry of metal hydride reductions2,3,4,5 an
Reaeived 4 June 1959) A STKDY of the addition of phenyllithimn to 3-substituted pyridinez m.z undertaken to detemine the orientatfon of the entering phenyl group, . While this work was in progrees W&leg et al\*' reported that the reaction of 3-phenylpyridine I(R -C H 65 ) with phenyllithium II wag a
## Abstract The rates for the reduction of ketones with sodium borohydride are interpreted in terms of two parameters, both derived from forceβfield calculations; __i.e.__ the strain difference between alcohol and ketone (Ξ strain) and the steric hindrance towards approach of the hydride R. Models