1998 indole derivatives, isoindole derivatives indole derivatives, isoindole derivatives R 0140 09 -123 The Reaction of Nitrones with Indoles. Synthesis of Asymmetrical Diindolylalkanes. -Indole reacts with nitrones (II) derived from aliphatic aldehydes in the presence of HCl (generated in situ from
The reaction of nitrones with indoles. Synthesis of asymmetrical diindolylalcanes
✍ Scribed by Jean-Noël Denis; Hélène Mauger; Yannick Vallée
- Book ID
- 104258341
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 203 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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The reaction of nitrones with various indole derivatives has been studied. When the reaction was promoted by ClSiMe 3 , the isolated products were 3,3 H -diindolylalkanes. With HCl as the activating reagent, 3-indolylhydroxylamines were isolated. The diastereoselectivity of this condensation with a
As part of our continuing study of the use of N-aryl nitrones in ortho-selective aromatic substitution reactions l-3 , we have investigated the reaction of a number of such nitrones with dichloroketene. These reactions lead to adducts which can be hydrolysed by boiling water or aqueous acid to isati