The reaction of melphalan with deoxyguanosine and deoxyguanylic acid
β Scribed by Martin R. Osborne; Philip D. Lawley
- Book ID
- 113137541
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 531 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0009-2797
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It was found that deoxyguanylic acid (dGMP) can form a complex with Tb(|II) at pH 6.9 7.5, which then emits the strong characteristic fuorescence of Tb(IIl). Excitation is at 290 nm and emission wavelengths are 490 nm and 545 nm. A linear relation is obtained between the fluorescence intensity and d
The purine moiety of guanosine is known to react with epoxides and P-propiolactone at the 7-nitrogen (1, 2), with N-acetoxy-N-Z-fluorenylacetamide at the B-carbon (3); and reversibly with formaldehyde (4, 5, 6) at the amino group of the 2-position, and with 1,2-dicarbonyl
## Abstract Reaction of 2β²βdeoxyguanosine with glyceraldehyde under physiological conditions leads to the formation of ammonium 2β[9β(2βdeoxyβΞ²βDβribofuranosyl)β6,9βdihydroβ6βoxoβ1__H__βpurinβ2βylamino]propionate (8). The same substance can be detected in 2β²βdeoxyguanosine/glucose reaction mixtures