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The reaction of deoxy-sickle cell hemoglobin with hydroxyurea

โœ Scribed by Daniel B. Kim-Shapiro; S.Bruce King; Howard Shields; Christopher P. Kolibash; W.Lyle Gravatt; Samir K. Ballas

Book ID
117481870
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
248 KB
Volume
1428
Category
Article
ISSN
0304-4165

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โœ D. Roa; P. Kopsombut; M. d. P. Aguinaga; E. A. Turner ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 104 KB ๐Ÿ‘ 2 views

Use of hydroxyurea (HU) to treat sickle cell disease is usually associated with increments in fetal hemoglobin (Hb F) production; however, in vitro studies show that HU may also induce hemoglobin denaturation. Whole blood samples from Hb AA, Hb AS, and Hb SS patients were treated in vitro with 100,