Variation in the level of fetal hemoglobin (HbF) accounts for much of the clinical heterogeneity observed in patients with sickle cell disease (SCD). The HbF level has emerged as an important prognostic factor in both sickle cell pain and mortality, and a % HbF of 10-20% has been suggested as a thre
Concordant fetal hemoglobin response to hydroxyurea in siblings with sickle cell disease
β Scribed by Martin H. Steinberg; Ersi Voskaridou; Abdullah Kutlar; Dimitris Loukopoulos; Mabel Koshy; Samir K. Ballas; Oswaldo Castro; Franca Barton
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 76 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0361-8609
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## Abstract A 21βyearβold man with homozygous sickle cell disease maintained on hydroxyurea for 1 year developed thrombosis of the superior sagittal, right transverse, and right sigmoid dural sinuses with a large venous infarct. He was successfully treated with endovascular thrombolysis. Investigat
Radial immunodiffusion (RID), alkaline cellulose acetate electrophoresis, and highperformance liquid chromatography (HPLC) were compared for quantitating the elevated (> 10%) level of fetal hemoglobin (HbF) found in the red blood cells of sickle cell disease patients undergoing treatment with hydrox