Variation in the level of fetal hemoglobin (HbF) accounts for much of the clinical heterogeneity observed in patients with sickle cell disease (SCD). The HbF level has emerged as an important prognostic factor in both sickle cell pain and mortality, and a % HbF of 10-20% has been suggested as a thre
Protective role of hemoglobin and fetal hemoglobin in early kidney disease for children with sickle cell anemia
โ Scribed by Jeffrey Lebensburger; Stephen M. Johnson; David J. Askenazi; Nigel L. Rozario; Thomas H. Howard; Lee M. Hilliard
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 75 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0361-8609
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Radial immunodiffusion (RID), alkaline cellulose acetate electrophoresis, and highperformance liquid chromatography (HPLC) were compared for quantitating the elevated (> 10%) level of fetal hemoglobin (HbF) found in the red blood cells of sickle cell disease patients undergoing treatment with hydrox