The reaction of 3,4-diamino-1,2,5-oxadiazoles with formaldehyde
✍ Scribed by A. Kakanejadifard; A. Saniei; F. Delfani; M. Farnia; G. R. Najafi
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2007
- Tongue
- English
- Weight
- 137 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-152X
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✦ Synopsis
Abstract
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The compounds 5,6‐dihydro‐4__H__‐imidazo[4,5‐c][1,2,5]oxadiazole (3a, RH), 4,6,10,12‐tetramethyl‐5,6,11,12‐tetrahydro‐4__H__,10__H__‐bis(1,2,5)oxadiazolo[3,4‐d:3′,4′‐I][1,3,6,8]tetraazecine (4b, RCH~3~), N^3^,N^3^′‐methylenebis‐3,4‐diamino‐1,2,5‐oxadiazole (5a, RH) and N^3^,N^3^′‐methylenebis(N,N′‐dimethyl‐3,4‐diamino‐1,2,5‐oxadiazolee) (5b, RCH~3~) were synthesized from the reaction of formaldehyde with 3,4‐diamino‐1,2,5‐oxadiazole and N,N′‐3,4‐dimethylamino‐1,2,5‐oxadiazole in an acetonitrile.
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## Abstract Reaction of the 1‐substituted‐3‐cyano‐isothioureas **6** with hydroxylamine gave mixtures of the 5‐amino‐3‐substituted‐amino‐1,2,4‐oxadiazoles **1** and the isomeric 3‐amino‐5‐substituted‐amino‐1,2,4‐oxadiazoles **8** in which **1** usually predominated. The structural assignment of the
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