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The reaction of 3-ethoxy-2-oxobutyraldehyde bis (thiosemicarbazonato) copper(II) with thiols

✍ Scribed by David H. Petering

Publisher
Elsevier Science
Year
1972
Weight
871 KB
Volume
1
Category
Article
ISSN
0006-3061

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✦ Synopsis

The copper complex, 3-ethoxy-2axobutyraldehyde bis(thiosemicarbazonato) copper( slowly oxidizes thiol groups. Under conditions of excess thiol, the reaction leads to the dissociation of CuKTS_ On the basis of pH and concentration studies of the rate of reaction, mechanisms are proposed for the reaction of CuKTS with mono-and dithiols. The rates of reaction of CuKTS with coenzyme A and dihydrolipoate have been measured. These results are discussed terms of proposed sites of the antitumor activity of CllKTS.

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