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The Rationale for Inhibiting 5α-Reductase Isoenzymes in the Prevention and Treatment of Prostate Cancer

✍ Scribed by Tindall, Donald J.; Rittmaster, Roger S.

Book ID
122614141
Publisher
Lippincott Williams and Wilkins
Year
2008
Tongue
English
Weight
639 KB
Volume
179
Category
Article
ISSN
0022-5347

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BACKGROUND. Steroid 5a-reductase is essential for the intracellular accumulation of dihydrotestosterone (DHT), which mediates androgen effects on target tissue. METHODS. In the present study, we describe the differential expression and cellular localization of 5a-reductase 1 and 2 isoenzymes in the