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The “Raman spectroscopic signature of life” is closely related to haem function in budding yeasts

✍ Scribed by Liang-da Chiu; Hiro-o Hamaguchi

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 157 KB
Volume: 4
Category: Article
ISSN: 1864-063X
DOI: 10.1002/jbio.201000029

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✦ Synopsis

Abstract

HEM1 gene encodes δ‐aminolevulinate synthase that is required for haem synthesis. It is an essential gene for yeast survival. The Raman spectra of HEM1 knockout (hem1Δ) yeast cells lacks a Raman band at 1602 cm^–1^ that has been shown to reflect cell metabolic activity. This result suggests that the molecule giving rise to the“Raman spectroscopic signature of life” is closely related to haem functions in the cell. High amount of squalene is also observed in the hem1Δ strain, which is another new discovery of this study. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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## Abstract The ‘Raman spectroscopic signature of life’ is a Raman band at 1602 cm^−1^ that sharply reflects the metabolic activity of cell mitochondria. Here we report the study of thissignature in isolated yeast mitochondria. The existence and behaviour of the 1602 cm^−1^ band in isolated mitocho