The R620W C/T polymorphism of the gene PTPN22 is associated with SLE independently of the association of PDCD1
✍ Scribed by Reddy, M V Prasad Linga; Johansson, M; Sturfelt, G; Jönsen, A; Gunnarsson, I; Svenungsson, E; Rantapää-Dahlqvist, S; Alarcón-Riquelme, M E
- Book ID
- 110037759
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 92 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1466-4879
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## Abstract ## Objective To determine any associations of the __PTPN22__ R620W single‐nucleotide polymorphism (SNP) with systemic sclerosis (SSc) or with anticentromere antibody (ACA)–positive or anti–topoisomerase I (anti–topo I) antibody–positive SSc, in a case–control study of US white, black,
## Abstract ## Objective The R620W (1858C→T) polymorphism in __PTPN2__2 has been implicated in type 1 diabetes mellitus, rheumatoid arthritis, Graves' disease, Hashimoto thyroiditis, autoimmune thyroid disease, and systemic lupus erythematosus (SLE). The aim of this study was to evaluate this poly