The functional R620W variant of the PTPN22 gene is associated with celiac disease
✍ Scribed by I. Santin; A. Castellanos-Rubio; A. M. Aransay; L. Castaño; J. C. Vitoria; J. R. Bilbao
- Book ID
- 110892726
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 77 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0001-2815
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## Abstract ## Objective To determine any associations of the __PTPN22__ R620W single‐nucleotide polymorphism (SNP) with systemic sclerosis (SSc) or with anticentromere antibody (ACA)–positive or anti–topoisomerase I (anti–topo I) antibody–positive SSc, in a case–control study of US white, black,
## Abstract ## Objective The R620W (1858C→T) polymorphism in __PTPN2__2 has been implicated in type 1 diabetes mellitus, rheumatoid arthritis, Graves' disease, Hashimoto thyroiditis, autoimmune thyroid disease, and systemic lupus erythematosus (SLE). The aim of this study was to evaluate this poly