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The Quality of Compressed Tablets, Particularly as to Solubility and Ease of Disintegration*

✍ Scribed by Husa, William J.


Publisher
Elsevier
Year
1928
Weight
283 KB
Volume
17
Category
Article
ISSN
0898-140X

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The inΒ―uence of compression force to inner core tablet or to outer coating layer of the compression-coated tablet on the function of time-controlled disintegration was investigated. The inner core tablet was directly compacted by sodium diclofenac (model drug) and ethylcellulose (EC) with 4.6-mm par

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The effect of excipient, drug, and osmotic agent loaded in the inner core tablet on the time-controlled disintegration of compression-coated tablet prepared by direct compression with micronized ethylcellulose was investigated. The excipients [spray-dried lactose, hydroxypropyl methyl cellulose, sod

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T h e effect of compressin several mesh sizes of lactose, sodium bicarEonate, and magnesium trisilicate granulations into tablets was determined. A definite relationship was found to exist between the particle size of the granulation of a particular substance and the disintegration rate, per cent of