The Effect of Granule Size Upon Disintegration Time and Capping in Compressed Tablets**Received June 30, 1958 from the Ohio State University, Columbus 10.
✍ Scribed by Forlano, Albert J. ;Chavkin, Leonard
- Publisher
- Elsevier
- Year
- 1960
- Weight
- 261 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0095-9553
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✦ Synopsis
T h e effect of compressin several mesh sizes of lactose, sodium bicarEonate, and magnesium trisilicate granulations into tablets was determined. A definite relationship was found to exist between the particle size of the granulation of a particular substance and the disintegration rate, per cent of capping, and other physical tablet characteristics. A definition of the term fines was also proposed.
HE PARTICLE SIZE of the granulated material is Tan important determinant of the characteristics of t h e finished compressed tablet. The purpose of this investigation was t o determine the effect of compressing various mesh sizes of lactose, sodium bicarbonate, and magnesium trisilicate granulations into tablets, separately. The effect of granule size upon t h e following characteristics were determined : (a) disintegration rate, (b) frequency of capping, and (c) production problems associated with each mesh size.
The determination of a definition for the commonly used term, fines, and the respective proportion of each mesh size in the granulations were also considered pertinent to this study.