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The Putative Oncogene PRAD1 Encodes a Novel Cyclin

✍ Scribed by Arnold, A.; Motokura, T.; Bloom, T.; Kronenberg, H.; Ruderman, J.; Juppner, H.; Kim, H.G.

Book ID
111929069
Publisher
Cold Spring Harbor Laboratory Press
Year
1991
Tongue
English
Weight
503 KB
Volume
56
Category
Article
ISSN
0091-7451

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The cyclin D1/PRAD1 oncogene, a key regulator of the G 1 phase of the cell cycle, has been incriminated in the pathogenesis of human neoplasia. Cyclin D1 was also demonstrated to be identical to the long-sought bcl-1 oncogene in B-cell malignancies with the t(11;14)(q13;q32) translocation. We report