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The Purines: Potent and Versatile Small Molecule Inhibitors and Modulators of Key Biological Targets

✍ Scribed by Michel Legraverend; David S. Grierson


Publisher
John Wiley and Sons
Year
2006
Weight
8 KB
Volume
37
Category
Article
ISSN
0931-7597

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Cover Picture: Modulators of the Kynuren
✍ Roberto Pellicciari; Rosaβ€…C. Rizzo; Gabriele Costantino; Maura Marinozzi; Laura πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 58 KB

**The cover picture shows** one branch of the kynurenine pathway of tryptophan metabolism, which is mainly localized in astrocytes. One key metabolite, kynurenic acid (KYNA), is transported in the extracellular space, where it modulates synaptically localized Ξ±7β€…nicotinic acetylcholine receptors and