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Modulators of the Kynurenine Pathway of Tryptophan Metabolism: Synthesis and Preliminary Biological Evaluation of (S)-4-(Ethylsulfonyl)benzoylalanine, a Potent and Selective Kynurenine Aminotransferase II (KAT II) Inhibitor

✍ Scribed by Roberto Pellicciari; Rosa C. Rizzo; Gabriele Costantino; Maura Marinozzi; Laura Amori; Paolo Guidetti; Hui-Qiu Wu; Robert Schwarcz

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
100 KB
Volume
1
Category
Article
ISSN
1860-7179

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Cover Picture: Modulators of the Kynuren
Cover Picture: Modulators of the Kynurenine Pathway of Tryptophan Metabolism: Synthesis and Preliminary Biological Evaluation of (S)-4-(Ethylsulfonyl)benzoylalanine, a Potent and Selective Kynurenine Aminotransferase II (KAT II) Inhibitor (ChemMedChem 5/2006)
✍ Roberto Pellicciari; Rosa C. Rizzo; Gabriele Costantino; Maura Marinozzi; Laura 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 58 KB

**The cover picture shows** one branch of the kynurenine pathway of tryptophan metabolism, which is mainly localized in astrocytes. One key metabolite, kynurenic acid (KYNA), is transported in the extracellular space, where it modulates synaptically localized α7 nicotinic acetylcholine receptors and