The proto-oncogene BCL-6 is expressed in olfactory sensory neurons
โ Scribed by Joji M. Otaki; Douglas T. Fearon; Haruhiko Yamamoto
- Book ID
- 116774674
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 791 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0168-0102
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BCL-6 is an important regulator of the immune system. It is required for GC formation and T cell dependent antibody responses. Mice deficient in BCL-6 fail to form GC and mount reduced levels of T cell-dependent antibody responses. BCL-6 (-/-) mice, in addition, develop a massive inflammatory respon
The advent of recombinant DNA technology has led to the identification in the DNA of normal animal cells of over 30 proto-oncogenes that are homologous to retroviral transforming genes. One of these encodes a protein kinase (pp60c-sr") of unknown function, that is preferentially synthesized in brain