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The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells

✍ Scribed by Phan, Ryan T.; Dalla-Favera, Riccardo


Book ID
109893675
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
354 KB
Volume
432
Category
Article
ISSN
0028-0836

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BCL-6 is an important regulator of the immune system. It is required for GC formation and T cell dependent antibody responses. Mice deficient in BCL-6 fail to form GC and mount reduced levels of T cell-dependent antibody responses. BCL-6 (-/-) mice, in addition, develop a massive inflammatory respon