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The proteosome inhibitor MG132 sensitizes MIAPaCa-2 pancreatic tumor cells to tumor necrosis factor (TNF)-induced apoptosis through stabilization of the NFκB-IκB complex

✍ Scribed by Fortunato, F.; Barve, S.; Joshi-Barve, S.; Gates, L.K.


Book ID
123265194
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
180 KB
Volume
114
Category
Article
ISSN
0016-5085

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## Abstract Resistance to tumor necrosis factor (TNFα)‐induced apoptosis in various cancer cells has been attributed to the activation of the transcription factor NF‐κB. Ebselen (2‐phenyl‐1,2‐benzisoselenazol‐3[2H]one)—a selenoorganic compound is known to prevent TNFα‐mediated NF‐κB activity. As gl