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Tumor necrosis factor α sensitizes malignant cells to chemotherapeutic drugs via the mitochondrial apoptosis pathway independently of caspase-8 and NF-κB

✍ Scribed by Schmelz, Karin; Wieder, Thomas; Tamm, Ingo; Müller, Antje; Essmann, Frank; Geilen, Christoph-C; Schulze-Osthoff, Klaus; Dörken, Bernd; Daniel, Peter-T


Book ID
110068916
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
667 KB
Volume
23
Category
Article
ISSN
0950-9232

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## Abstract Resistance to tumor necrosis factor (TNFα)‐induced apoptosis in various cancer cells has been attributed to the activation of the transcription factor NF‐κB. Ebselen (2‐phenyl‐1,2‐benzisoselenazol‐3[2H]one)—a selenoorganic compound is known to prevent TNFα‐mediated NF‐κB activity. As gl