The incorporation of digitonin 0.2% w/v in cacodylate buffered glu- taraldehyde reduces the amount of cholesterol extracted in the dehydrating (lipid extracting) solutions. The fixative enhances membrane structure and results in the preservation of a double minor period in peripheral myelin. The per
The protein antigens of peripheral nerve myelin
β Scribed by Dr. John N. Whitaker
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 877 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
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Peripheral nerves of mutant mice deficient for peripheral myelin protein 22 (PMP22) or connexin32 (Cx32) display similar pathologies as observed in hereditary human peripheral neuropathies. Mice lacking PMP22 develop focal hypermyelination followed by myelin degeneration and axonal atrophy. Cx32-def
Peripheral myelin protein 22 (PMP22) is a small, hydrophobic glycoprotein, which is most prominently expressed by Schwann cells as a component of compact myelin of the peripheral nervous system (PNS). Recent progress in molecular genetics revealed that mutations affecting the PMP22 gene including du
## Abstract The disintegrin and metalloproteinase 10 (ADAM10) is a membraneβanchored metalloproteinase with both proteolytic and disintegrin characteristics. Here, we investigate the expression, regulation, and functional role of ADAM10 in axonal outgrowth and myelination of the peripheral nerve. E