The Protective Effects of Spirulina in Cyclophosphamide Induced Nephrotoxicity and Urotoxicity in Rats
✍ Scribed by Sinanoglu, Orhun; Yener, Arzu Neşe; Ekici, Sinan; Midi, Ahmet; Aksungar, Fehime Benli
- Book ID
- 118502936
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 670 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0090-4295
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## Abstract Cyclosporine (CsA) causes a dose‐related decrease in renal function in experimental animals and humans. The generation of reactive oxygen species (ROS) has been implicated in CsA‐induced nephrotoxicity. It was previously shown that __Spirulina__, a blue‐green algae, with antioxidant pro
Key words: nephrotoxicity; cisplatin; radical scavengers; methimazole; rat In adult rats 6 mg kg -1 body wt. cisplatin given i.p. was nephrotoxic. Four days of i.p. treatment with 40 mg kg -1 body wt. methimazole, which started 1 day before CP, prevented increases in blood urea nitrogen and in the r