The Protective Effects of Ipratropium Bromide and Terbutaline on Distilled Water-induced Bronchoconstriction

✍ Scribed by C.A.R. Groot; J.-W.J. Lammers; J. Festen; C.L.A. van Herwaarden

• Publisher: Elsevier
• Year: 1994
• Tongue: English
• Weight: 226 KB
• Volume: 7
• Category: Article
• ISSN: 0952-0600
• DOI: 10.1006/pulp.1994.1006

✦ Synopsis

SUMMARY: In a randomized, double-blind, placebo-controlled study, we investigated the protective effects of ipratropium bromide (160 \mu \mathrm{g}) and (320 \mu \mathrm{g}) and terbutaline (500 \mu \mathrm{g}) on ultrasonically nebulized distilled water (UNDW)induced bronchoconstriction in nine stable asthmatic patients. Both drugs caused a significant increase ((P<0.001)) in baseline (F E V_{1}) with no significant differences between the drugs or both doses of ipratropium bromide. Pre-inhalation of ipratropium bromide (320 \mu \mathrm{g}) and terbutaline (500 \mu \mathrm{g}) inhibited UNDW-induced bronchoconstriction ((P<0.01)), whereas ipratropium bromide (160 \mu \mathrm{g}) had no protective effect. The protective effects of ipratropium bromide showed a large interindividual variation. There was no correlation between the increase in baseline (\mathrm{FEV}{1}) and (\mathrm{PD}{20} \mathrm{UNDW}), indicating that the protective effect on UNDW-induced bronchoconstriction is not dependent on the bronchodilation induced by terbutaline and ipratropium bromide. It also appears that the UNDW-induced bronchoconstriction is at least partly vagally mediated.