✦ LIBER ✦

The proliferation rate of T and B lymphocytes in cerebrospinal fluid

✍ Scribed by R. S. Thomas; W. Beuche; K. Felgenhauer

Publisher: Springer
Year: 1991
Tongue: English
Weight: 614 KB
Volume: 238
Category: Article
ISSN: 0340-5354
DOI: 10.1007/bf00319706

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✦ Synopsis

An immunocytochemical method is presented by which individual proliferating T and B lymphocytes can be detected in the cerebrospinal fluid (CSF) of patients with inflammatory and neoplastic diseases of the central nervous system. The absolute numbers of proliferating T and B lymphocytes were approximately equal, so that only a minority of the strongly prevailing T-cell population proliferates in the CSF during the immune process. The highest proliferation (25.7%) was found within the small subset of activated, i.e. cytoplasmic immunoglobulin-containing, B lymphocytes. This provides further evidence that these cells are not the terminally differentiated plasma cells of classical cytology but progenitor cells capable of further proliferation. B-cell lymphomas could be easily identified. The detection of abnormally proliferating cell subsets could help in the differentiation of opportunistic infection from leukaemic infiltration.

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